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Publications
This section aims to enlist a number of publications from our own center regarding
transfer of blastocysts.
In the registry itself you will be able to find a number of relevant publications
from various other centers
IVF team, Diaconessenhuis Voorburg
Rijnders
PM, Jansen CAM
The predictive value of day 3 embryos-morphology for blastocyst formation and
implantation rate at day 5 in IVF
Human Reproduction 1998; 13: 2869-73.
This paper describes that the predictive value of the morphological
appearance of day 3 embryos for the subsequent blastocyst formation is limited: only about
half of class 1 and 2 embryos reach the blastocyst stage, whilst even one in five class 3
and 4 embryos actually become blastocysts. It has appeared in the October
issue of Human
Reproduction. Part of the data of this paper have been presented at the ESHRE meeting in
Maastricht, 1996, and at the World Congress
of IVF in Vancouver, 1997. It had been selected
as a prize paper, and the extended abstract from this can be found on Ferti-Net.
Related publications:
Rijnders PM, Jansen CAM,
The predictive value of day 3 embryo
morphology for blastocyst formation and implantation rate at day 5 in IVF. Hum. Reprod.
1996; 11S: 86
Rijnders
PM, Jansen CAM
The predictive value of day 3 embryo
morphology for blastocyst formation and implantation rate at day 5 in IVF (extended)
Fertinet/special interest/embryology 1996
(registration on-site required)
Rijnders PM, Jansen CAM
Selecting embryos and patients for transfer in IVF after
expression of the embryonic genome. J.Ass. Reprod. Gen. 1997: 14: 91S)
Van Os HC, Rijnders PM, Jansen CAM
Transfer of blastocysts in the human: course and outcome of pregnancy and offspring
Hum. Reprod. 1998: 13: 6S
This abstract has been presented at the ESHRE Meeting in 1998 in
Goteborg,
Sweden. The course and outcome of pregnancies obtained after transfer of blastocysts has
been compared to that of transfer after day 2 and 3, and described. In our hands the fetal
loss rate (ectopics and miscarriage) is similar in all three groups, and 2 major
congenital abnormalities were detected in 75 babies. One pregnancy was terminated, the
other child was born with aplasia of the left fore arm.
Rijnders
PM, Jansen CAM Rijnders PM, Jansen CAM
Influence of group culture and culture volume on the formation of human blastocysts in
IVF and ICSI: a prospective randomised study.
Hum. Reprod. 1999: 14:2333- 8
In this paper we compared the rate of blastocyst formation in
different culture conditions between day 3 and day 5 (small and large volume, and communal
growth). We did not find significant differences between any of the modes. The only
significant finding was a slight decrease in the blastocyst formation rate in relation to
the number of oocytes. Each oocyte more means a 6 % decrease in the blastocyst formation
rate. These data have been presented at the ESHRE meeting in Goteborg 1998.
Related publications:
Rijnders PM, Jansen CAM
Influence of group culture and culture volume on the formation of human blastocysts in IVF
and ICSI: a prospective randomised study.
Hum. Reprod. 1998: 13: 7 (text)
Rijnders PM, Van Os HC, Jansen CAM.
Increased incidence of monozygotic twinning following the transfer of blastocysts in human
IVF/ICSI
Fertil. Steril. 1998; 70: S 15- 6
In this study we compared the rate of monozygotic
twinning after standard day 2 or 3 transfer in IVF/ICSI with that of transfer of
blastocysts after 5 days.
In the natural condition, after spontaneous pregnancies this rate is remarkably constant
all over the world at about 3 per 1000 births. After day 2 it was 4 per 1000, day 3: 5 per
1000 but after day 5 transfer it was 25 per 1000, a significant five to six fold increase
over baseline. These data have been presented in 1998 at the ASRM/ IFFS meeting in San
Francisco. We were the first in the world to show that there is an increased
rate in monozygotic twinning after replacement of blastocysts. Now there are several confirmations by
other groups. The rate seems
independent of zona removal procedures such as by pronase elution.
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